Key result
A synthetic peptide containing NS4A amino acids 21 to 32 is necessary and sufficient to stimulate the proteolytic activity of the HCV NS3 protease at all trans-cleavage sites.
Population
Rabbit reticulocyte expression system and synthetic peptides (in vitro model)
Design
Preclinical
Authors
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Refines NS3-NS4A interaction model; extends basic HCV virology but leaves open any therapeutic translation.
The minimal domain of the hepatitis C virus NS4A protein necessary to activate the NS3 protease is located between amino acids 21 and 32.
Tomei et al. (1996) studied Hepatitis C virus (HCV) infection. NS4A amino acids 21 to 32 synthetic peptide was evaluated on Activation of NS3 protease trans-cleavage activity. A synthetic peptide containing NS4A amino acids 21 to 32 is necessary and sufficient to stimulate the proteolytic activity of the HCV NS3 protease at all trans-cleavage sites.
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