Key result
Aortic stenosis in rats significantly increased the frequency of supraventricular premature beats compared to controls (99 vs 0.70 per 24 h, p<0.05).
Why the study?
What are the characteristics of spontaneous arrhythmias in various rat models of cardiac hypertrophy and senescence?
Population
47 male Wistar rats, including young controls 1-2 months old and four groups with cardiac hypertrophy…
Comparison
Induction of cardiac hypertrophy via… vs Young control rats (1-2 months old)
Design
Preclinical
Follow-up
24 hours
Authors
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Supports aortic stenosis rat models for spontaneous supraventricular arrhythmias without ischemia; leaves open human translation.
What are the characteristics of spontaneous arrhythmias in various rat models of cardiac hypertrophy and senescence?
Absolute Event Rate: 99% vs 0.7%
p-value: p=<0.05
Senescent rats and those with aortic stenosis serve as valid experimental models for spontaneous supraventricular arrhythmias occurring without ischemia.
Carré et al. (1992) studied Cardiac hypertrophy and senescence (n=47). Cardiac hypertrophy models (thyroxine, aortic stenosis, senescence, S-DOCA-salt) vs. Young controls was evaluated on Incidence of supraventricular premature beats per 24 h (p=<0.05). Aortic stenosis in rats significantly increased the frequency of supraventricular premature beats compared to controls (99 vs 0.70 per 24 h, p<0.05).
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