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February 1, 2001Journal of Cardiovascular Pharmacology

Renin-Angiotensin System Contribution to Cardiac Hypertrophy in Experimental Hyperthyroidism: An Echocardiographic Study

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Why the study?

Does valsartan prevent left ventricular hypertrophy in Wistar rats with experimental hyperthyroidism?

Population

Wistar rats with experimental hyperthyroidism induced by daily intraperitoneal injection of L-thyroxine 0.1…

Comparison

Valsartan 10 mg/kg per day for 15 days vs Control conditions (no valsartan)

Design

Preclinical

Follow-up

15 days

Authors

ABAlexandra BassetUniversité Claude Bernard Lyon 1JBJocelyne BlancCentre National de la Recherche ScientifiqueEMEmmanuel MessasVascular / Pulmonary Vascular

Discussion

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Implication

Hypothesis-generating in hyperthyroid rats; leaves open clinical translation to thyrotoxic cardiomyopathy.

Structured PICO

Does valsartan prevent left ventricular hypertrophy in Wistar rats with experimental hyperthyroidism?

P
Population
Wistar rats with experimental hyperthyroidism induced by daily intraperitoneal injection of L-thyroxine (T4) 0.1 mg/kg per day for 15 days, and euthyroid controls (n=24 in first series).
I
Intervention
Valsartan 10 mg/kg per day for 15 days
C
Comparator
Control conditions (no valsartan)
O
Outcome
Left ventricular mass and geometry (LV end-diastolic posterior wall and septal thickness) measured by two-dimensional time-movement echocardiography on the 15th daysurrogate

In a rat model of experimental hyperthyroidism, treatment with the angiotensin II receptor blocker valsartan prevented the development of concentric left ventricular hypertrophy.

Cite This Study

Basset et al. (2001) studied this question.

synapsesocial.com/papers/6a70d66535aa2c282ce22942https://doi.org/10.1097/00005344-200102000-00004

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of the Angiotensin II Antagonist Valsartan on Left Ventricular Hypertrophy in Patients With Essential Hypertension1998 · 198 citations
  2. 2The Angiotensin II Receptor and the Actions of Angiotensin II1990 · 124 citations
  3. 3Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy1999 · 59 citations
  4. 4Blockade of the Renin-Angiotensin System in Cardiac Pressure-Overload Hypertrophy in Rats1995 · 155 citations
  5. 5Effects of thyroid hormone on cardiac size and myosin content of the heterotopically transplanted rat heart.1986 · 171 citations