Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1999Journal of EndocrinologyOpen Access

Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the local renin-angiotensin system contribute to hyperthyroidism-induced cardiac hypertrophy in a rat model?

Population

Sprague-Dawley rats

Comparison

Daily i.p. injection of thyroxine plus chronic… vs Chronic angiotensin II infusion alone for 28 days

Design

Preclinical

Follow-up

28 days

Authors

HKHiroyuki KoboriGeneral / Preventive / LipidsAIAtsuhiro IchiharaGeneral / Preventive / LipidsYMYutaka MiyashitaSuzuki (Japan)

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for local cardiac RAS in rat hyperthyroid hypertrophy; leaves open human translation and therapeutic targeting.

Structured PICO

Does the local renin-angiotensin system contribute to hyperthyroidism-induced cardiac hypertrophy in a rat model?

P
Population
Sprague-Dawley rats
I
Intervention
Daily i.p. injection of thyroxine (0.1 mg/kg per day) plus chronic angiotensin II infusion (40 ng/min via mini-osmotic pumps) for 28 days
C
Comparator
Chronic angiotensin II infusion (40 ng/min via mini-osmotic pumps) alone for 28 days
O
Outcome
Cardiac hypertrophy and cardiac expression of renin mRNA, cardiac renin, and cardiac angiotensin IIsurrogate

The local renin-angiotensin system, rather than the circulating system, plays the primary role in hyperthyroidism-induced cardiac hypertrophy.

Cite This Study

Kobori et al. (1999) studied this question.

synapsesocial.com/papers/6a70d66535aa2c282ce22944https://doi.org/10.1677/joe.0.1600043
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of the renin-angiotensin system in the development of thyroxine-induced hypertension1997 · 24 citations
  2. 2Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism1997 · 55 citations
  3. 3Thyroid hormone stimulates renin synthesis in rats without involving the sympathetic nervous system1997 · 55 citations
  4. 4Thyroid hormone effects on cardiac gene expression independent of cardiac growth and protein synthesis1992 · 52 citations
  5. 5Blockade of the Renin-Angiotensin System in Cardiac Pressure-Overload Hypertrophy in Rats1995 · 155 citations