What is the clinical evidence from this study?

Study design: Other. Population: experimental hyperthyroidism. Intervention: triiodothyronine (T3) vs. saline. Primary outcome: changes in angiotensin II receptors and the plasma renin-angiotensin system.

March 1, 1993Cardiovascular Research

Cardiac angiotensin receptors in experimental hyperthyroidism in dogs

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Key result

Triiodothyronine-induced hyperthyroidism in dogs activates plasma RAS and upregulates LV, aortic, and liver angiotensin II receptors.

Authors

CSConrad SerniaUniversities UK CMColin D. MarchantUniversidad Andrés Bello LBLindsay Hansen Brown

Discussion

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Implication

Experimental hyperthyroidism activates RAS in dogs; leaves open relevance to human cardiovascular complications.

PICO

Population

Dogs subjected to experimental hyperthyroidism induced by subcutaneous injection of triiodothyronine for 14 days.

Intervention / Comparator

triiodothyronine (T3) vs saline (1 mg.kg-1 x d-1)

Primary Outcome

changes in angiotensin II receptors and the plasma renin-angiotensin system

Cite This Study

Sernia et al. (1993) studied experimental hyperthyroidism. triiodothyronine (T3) vs. saline was evaluated on changes in angiotensin II receptors and the plasma renin-angiotensin system. Triiodothyronine-induced hyperthyroidism in dogs activated the plasma renin-angiotensin system and upregulated left ventricular, aortic, and liver angiotensin II receptors.

synapsesocial.com/papers/6aa1f8fdc8d772f3c26ee2e2 https://doi.org/10.1093/cvr/27.3.423

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Cardiac angiotensin receptors in experimental hyperthyroidism in dogs

Discussion

Member takes

Implication

PICO

Cite This Study

Cardiac angiotensin receptors in experimental hyperthyroidism in dogs

Discussion

Member takes

Implication

PICO

Cite This Study

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