Nebulised salbutamol therapy produced a >20% fall in respiratory resistance in 18 of 20 wheezing children over 20 months of age, but no child under 18 months showed a >5% fall.
Observational (n=32)
Does nebulised salbutamol improve respiratory resistance in wheezing children aged 7 months to 3 years 7 months?
Nebulised salbutamol appears ineffective at reducing respiratory resistance in wheezing children under 18 months of age, but is effective in those over 20 months.
Using a modification of the forced oscillation technique we have measured respiratory resistance before and after nebulised salbutamol therapy in 32 wheezing children aged 7 months to 3 years 7 monts. 12 of the children were also studied in a total body plethysmograph. No child under 18 months of aged showed a greater than 5% fall in resistance or any fall in thoracic gas volume. In contrast, 18 of 20 children over 20 months of age showed a fall in resistance greater than 20%.
Lenney et al. (Sat,) conducted a observational in wheezing (n=32). Nebulised salbutamol vs. Baseline (before therapy) was evaluated on Fall in respiratory resistance. Nebulised salbutamol therapy produced a >20% fall in respiratory resistance in 18 of 20 wheezing children over 20 months of age, but no child under 18 months showed a >5% fall.