Key result
Nebulised salbutamol therapy produced a >20% fall in respiratory resistance in 18 of 20 wheezing children over 20 months of age, but no child under 18 months showed a >5% fall.
Why the study?
Does nebulised salbutamol improve respiratory resistance in wheezing children aged 7 months to 3 years 7 months?
Population
32 wheezing children aged 7 months to 3 years 7 months
Comparison
Nebulised salbutamol therapy vs Baseline (before therapy)
Design
Cohort
Follow-up
Immediate (before and after therapy)
Authors
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Salbutamol may not reduce resistance in wheezing infants <18 months; leaves open age-specific randomized trials before practice change.
Observational (n=32)
Does nebulised salbutamol improve respiratory resistance in wheezing children aged 7 months to 3 years 7 months?
Nebulised salbutamol appears ineffective at reducing respiratory resistance in wheezing children under 18 months of age, but is effective in those over 20 months.
Lenney et al. (1978) conducted an observational in wheezing (n=32). Nebulised salbutamol vs. Baseline (before therapy) was evaluated on Fall in respiratory resistance. Nebulised salbutamol therapy produced a >20% fall in respiratory resistance in 18 of 20 wheezing children over 20 months of age, but no child under 18 months showed a >5% fall.
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