Key result
Baroreceptors with C fibres in the aortic nerve have a much higher threshold to pressure than myelinated A fibres, contributing to sympathetic inhibition only at pressures well above normal.
Why the study?
Does acute increase in arterial pressure trigger sympathetic inhibition via aortic nerve C fibres in rabbits?
Population
Rabbits (model for aortic nerve C fibres)
Comparison
Acute increases in arterial pressure with A… vs Acute increases in arterial pressure with A and…
Design
Preclinical
Authors
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Highlights C-fiber baroreceptor activation only at supranormal pressures in rabbits; leaves open relevance to human sympathetic control in hypertension.
Does acute increase in arterial pressure trigger sympathetic inhibition via aortic nerve C fibres in rabbits?
Baroreceptors with C fibres in the rabbit aortic nerve have a much higher pressure threshold than myelinated A fibres, contributing to sympathetic inhibition only when pressure is increased well above normal resting levels.
Aars et al. (1978) studied this question. Acute increases in arterial pressure with A fibres blocked vs. Acute increases in arterial pressure with A and C fibres intact was evaluated on Changes in renal nerve activity (sympathetic inhibition). Baroreceptors with C fibres in the aortic nerve have a much higher threshold to pressure than myelinated A fibres, contributing to sympathetic inhibition only at pressures well above normal.
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