Key result
Renal denervation in young spontaneously hypertensive rats ameliorated reduced fractional excretion of lithium (10.2% vs 5.3% in sham) and prevented the early development of hypertension.
Why the study?
Does renal denervation prevent hypertension and improve proximal tubule solute reabsorption in young spontaneously hypertensive rats on a high sodium diet?
Population
3-week old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Renal denervation with 10% phenol and maintained… vs Sham surgery
Design
Preclinical
Follow-up
10 days
Authors
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Hypothesis-generating in hypertensive rat models; leaves open translation to human hypertension prevention.
Does renal denervation prevent hypertension and improve proximal tubule solute reabsorption in young spontaneously hypertensive rats on a high sodium diet?
Absolute Event Rate: 10.2% vs 5.3%
Renal denervation prevents the early development of hypertension and enhanced proximal tubule solute reabsorption in young spontaneously hypertensive rats on a high sodium diet.
Robert E. Beach (1992) studied Hypertension. Renal denervation vs. Sham surgery was evaluated on Fractional excretion of lithium (FELi) on a 2.2% sodium diet. Renal denervation in young spontaneously hypertensive rats ameliorated reduced fractional excretion of lithium (10.2% vs 5.3% in sham) and prevented the early development of hypertension.
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