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November 1, 1999AJP Heart and Circulatory Physiology

Age-related left ventricular function in the mouse: analysis based on in vivo pressure-volume relationships

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Why the study?

Does senescence decrease left ventricular contractile function in mice?

Population

18 mice (n=9 6-month-old young adult mice, n=9 16-month-old senescent mice)

Comparison

Senescence (16-month-old mice) vs Young adult mice (6-month-old)

Design

Preclinical

Authors

BYBo YangNanjing Agricultural UniversityDLDouglas F. LarsonUniversity of Maryland, BaltimoreRWRonald R. WatsonBrigham Young University

Discussion

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Implication

Senescence impairs coupling and contractility in mice; leaves open translation to human age-related HF.

Key Points

  • This study aims to analyze the effects of aging on left ventricular function in mice using pressure-volume relationships.
  • In vivo pressure-volume loop analysis in 6-month-old (young) and 16-month-old (senescent) mice (n=9 each).
  • Mice were anesthetized and instrumented with a conductance micromanometer catheter for data acquisition.
  • Contractile function significantly decreased in senescent mice as shown by reduced stroke volume index and ejection fraction (P < 0.001).
  • Load-independent parameters like preload recruitable stroke work were significantly decreased in senescent mice.
  • The ventricular-to-vascular coupling ratio increased threefold in senescent mice (P < 0.001).

Structured PICO

Does senescence decrease left ventricular contractile function in mice?

P
Population
18 mice (n=9 6-month-old young adult mice, n=9 16-month-old senescent mice)
I
Intervention
Senescence (16-month-old mice)
C
Comparator
Young adult mice (6-month-old)
O
Outcome
Left ventricular function assessed by in situ pressure-volume loop analysis (load-dependent and load-independent parameters)surrogate

Senescence in mice is associated with significant decreases in left ventricular contractile function and reduced mechanical efficiency, independent of arterial elastance.

Cite This Study

Yang et al. (1999) studied this question.

synapsesocial.com/papers/6a219ca884d1906bac5fd0cehttps://doi.org/10.1152/ajpheart.1999.277.5.h1906
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Measurement of intraventricular pressure and cardiac performance in the intact closed-chest anesthetized mouse1997 · 109 citations
  2. 2Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats1996 · 273 citations
  3. 3Age-dependent augmentation of cardiac endothelial NOS in a genetic rat model of heart failure1997 · 34 citations
  4. 4Age‐dependent changes in myosin composition correlate with enhanced economy of contraction in guinea‐pig hearts1998 · 69 citations
  5. 5Senescent Heart Compared With Pressure Overload–Induced Hypertrophy1997 · 58 citations