Key result
Aspirin hypersensitivity in PCI patients presents a clinical dilemma with few validated alternatives, though aspirin desensitization is a potential and safe option when practical.
Why the study?
How should aspirin hypersensitivity be managed in patients undergoing percutaneous coronary intervention?
How should aspirin hypersensitivity be managed in patients undergoing percutaneous coronary intervention?
This review provides a treatment algorithm for managing the challenging clinical scenario of aspirin hypersensitivity in patients requiring PCI.
Desensitization may be considered in select aspirin-hypersensitive PCI patients; leaves open need for validated alternatives in larger cohorts.
Aspirin plays a pivotal role in the management of patients with Coronary Artery Disease (CAD) with well-recognised benefits of reducing recurrent myocardial infarction and minimising the risk of stent thrombosis for those undergoing Percutaneous Coronary Intervention (PCI). Dual antiplatelet therapy is mandated for patients undergoing PCI and typically consists of aspirin and a P2Y12 receptor antagonist. Aspirin hypersensitivity poses a significant clinical dilemma, as the safety and efficacy of oral antiplatelet combinations that exclude aspirin have not been validated. Although, genuine hypersensitivity to aspirin is encountered infrequently, it can be challenging when managing patients with concomitant CAD given the paucity of safe and effective alternatives. Aspirin desensitization is a potential and safe option but may not always be practical. This review aims to highlight the challenges of aspirin hypersensitivity in patients undergoing PCI and propose a treatment algorithm to address this issue in clinical practice.
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Kassimis et al. (2018) conducted a review in Aspirin hypersensitivity in patients undergoing Percutaneous Coronary Intervention (PCI). Aspirin desensitization and alternative antiplatelet strategies was evaluated. Aspirin hypersensitivity in PCI patients presents a clinical dilemma with few validated alternatives, though aspirin desensitization is a potential and safe option when practical.
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