Key result
Anticancer drugs such as gemcitabine, therapeutic growth factors, cytokines, and monoclonal antibodies are identified as strong candidates for inducing capillary leak syndrome.
Why the study?
Capillary leaks can occur as adverse drug reactions to anticancer therapies, with severe cases presenting with cardiovascular collapse, shock, and death.
Certain anticancer drugs, including gemcitabine, cytokines, and monoclonal antibodies, are strongly associated with drug-induced capillary leak syndrome, a potentially fatal adverse reaction.
Answers are grounded in this paper and cite their sources.
May prompt vigilance for capillary leak syndrome with gemcitabine or monoclonal antibodies; leaves open prospective validation of risk.
The term capillary leak syndrome (CLS) describes the manifestations associated with an increased capillary permeability to proteins leading to an escape of plasma from the blood circulatory system to surrounding tissues, muscle, organs, or body cavities. This results clinically in the typical triad of hypotension, edema, and elevated hematocrit. The more severe cases of CLS may present with cardiovascular collapse, shock, and death. The most classic form of this pathology is represented by the idiopathic systemic CLS (SCLS) also called Clarkson's disease, but capillary leaks are also described as adverse drug reactions foremost among which are anticancer drugs. This review will focus on oncologic drugs such as gemcitabine, therapeutic growth factors or cytokines, and monoclonal antibodies (mAbs) that appear now as the strongest candidates for anticancer drug-induced CLS.
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Izzedine et al. (2022) conducted a review in Anticancer Drug-Induced Capillary Leak Syndrome. Anticancer drugs (gemcitabine, therapeutic growth factors, cytokines, monoclonal antibodies) was evaluated on Capillary leak syndrome. Anticancer drugs such as gemcitabine, therapeutic growth factors, cytokines, and monoclonal antibodies are identified as strong candidates for inducing capillary leak syndrome.
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