Key result
Allogeneic stem cell transplant conditioning linked to fatal capillary leak syndrome in refractory AML.
Case Report (n=1)
No
Highlights the rare but fatal complication of capillary leak syndrome during allogeneic hematopoietic stem cell transplantation.
Background: Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers the possibility of cure for hematological malignancies, various complications have been described. Capillary leak syndrome (CLS) has been previously observed in HSCT patients. CLS is a rare disease characterized by recurrent episodes of generalized edema and severe hypotension along with hypoproteinemia.Case Report: A 27-year-old Chinese man, diagnosed with refractory acute myeloid leukemia, was treated with a haploidentical stem cell transplant combined with an unrelated umbilical cord blood unit. The patient developed fatal CLS during the 9th day of the conditioning therapy. Conclusion: Since it is difficult to distinguish between CLS and other early complications during allo-HSCT, our report highlights the need for rigorous investigation of identifying CLS and the increasing need of insightful diagnosis to manage any incidence of CLS.
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Jiang et al. (2018) conducted a case report in Refractory Acute Myeloid Leukemia (n=1). Allogeneic hematopoietic stem cell transplantation was evaluated on Clinical course and survival. A 27-year-old man with refractory acute myeloid leukemia developed fatal capillary leak syndrome during conditioning therapy for allogeneic stem cell transplantation, resulting in death on day 42.
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