Key result
Newly diagnosed hypertension was associated with significantly increased serum hs-CRP levels compared to controls (0.57 mg/dL vs 0.25 mg/dL, P<0.001), particularly in concentric hypertrophy.
Why the study?
Is high-sensitivity C-reactive protein (hs-CRP) associated with left ventricular hypertrophy and diastolic dysfunction in patients with newly diagnosed hypertension?
Observational (n=115)
Is high-sensitivity C-reactive protein (hs-CRP) associated with left ventricular hypertrophy and diastolic dysfunction in patients with newly diagnosed hypertension?
Answers are grounded in this paper and cite their sources.
Elevated hs-CRP levels are significantly associated with concentric left ventricular hypertrophy and diastolic dysfunction in newly diagnosed hypertensive patients, highlighting a potential inflammatory component in hypertensive heart disease.
The authors aimed to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and presence of left ventricular hypertrophy and diastolic dysfunction in patients with hypertension. A total of 95 newly diagnosed hypertensive patients (mean age, 54±10 years) and 20 controls were included in this study. Patients were divided into four groups according to relative wall thickness as normal, concentric remodeling, concentric, and eccentric hypertrophy. hs-CRP was measured in all patients and serum hs-CRP level was shown to be increased in patients with hypertension compared with controls (0.57 mg/dL vs 0.25 mg/dL, respectively; P<.001). The hs-CRP level was highest in patients with concentric hypertrophy. When compared with controls, serum hs-CRP level was significantly higher in patients with concentric remodeling (0.61±0.3 mg/dL vs 0.43±0.5 mg/dL, P<.030) and concentric hypertrophy (0.69±0.3 mg/dL vs 0.43±0.5 mg/dL, P<.032). The present study shows that serum hs-CRP is significantly associated with left ventricular diastolic function and concentric hypertrophy in patients with hypertension.
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Seyfeli et al. (2015) conducted an observational in Newly diagnosed hypertension (n=115). Hypertension vs. Controls was evaluated on Serum hs-CRP level (p=<.001). Newly diagnosed hypertension was associated with significantly increased serum hs-CRP levels compared to controls (0.57 mg/dL vs 0.25 mg/dL, P<0.001), particularly in concentric hypertrophy.
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