Key result
Children with type 1 diabetes exhibited significantly higher mean platelet volume compared to healthy controls (10.47 vs 10.23 fL, p=0.0007), suggesting morphological evidence of platelet hyperreactivity.
Case-Control (n=778)
No
Absolute Event Rate: 10.47% vs 10.23%
p-value: p=0.0007
Children with type 1 diabetes exhibit morphological evidence of platelet hyperreactivity, which may predispose them to future cardiovascular events.
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May signal early thrombotic risk in pediatric type 1 diabetes; hypothesis-generating and requires prospective validation before any clinical application.
Małachowska et al. (2015) conducted a case-control in Type 1 diabetes mellitus (n=778). Type 1 diabetes mellitus vs. Healthy children (non-diabetic) was evaluated on Mean platelet volume (MPV) (p=0.0007). Children with type 1 diabetes exhibited significantly higher mean platelet volume compared to healthy controls (10.47 vs 10.23 fL, p=0.0007), suggesting morphological evidence of platelet hyperreactivity.
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