Key result
Type 2 diabetes is linked to ~5% higher mean platelet volume versus non-diabetic controls.
Why the study?
Platelets with altered morphology may be associated with increased risk of vascular complications in diabetes, but their role in evaluating type 2 diabetic patients is unclear.
Do patients with type 2 diabetes have altered platelet indices compared to non-diabetic controls, and do these indices correlate with vascular complications?
Population
100 type 2 diabetic patients and 100 non-diabetic controls aged 30-60 years at a university hospital outpatient clinic
Comparison
Type 2 diabetic patients vs non-diabetic controls
Design
Case-control study
Authors
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Platelet indices may serve as accessible markers in type 2 diabetes; leaves open prospective validation for vascular complications.
Case-Control (n=200)
No
Do patients with type 2 diabetes have altered platelet indices compared to non-diabetic controls, and do these indices correlate with vascular complications?
Absolute Event Rate: 8.69% vs 8.27%
p-value: p=0.018
Platelet indices (MPV, PCT, PDW) are elevated in type 2 diabetes and correlate with vascular complications, suggesting utility as simple biomarkers for early detection of long-term complications.
Alhadas et al. (2016) conducted a case-control in Type 2 diabetes mellitus (n=200). Type 2 diabetes mellitus vs. Non-diabetic patients was evaluated on Mean platelet volume (MPV) (p=0.018). Type 2 diabetes mellitus was associated with significantly higher mean platelet volume (8.69 vs 8.27 fl; p=0.018), plateletcrit, and platelet distribution width compared to non-diabetic controls.
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