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Sarcoplasmic reticulum calcium leak drives ventricular arrhythmias rather than heart failure progression, as rycal S36 treatment markedly reduces arrhythmias and improves survival in mice.
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Supports arrhythmia-specific targeting over broad HF modification; leaves open whether rycal S36 improves patient outcomes.
leak does not primarily influence contractile HF progression, whereas rycal S36 treatment markedly reduces ventricular arrhythmias, thereby improving survival in mice.
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Mohamed et al. (2018) studied this question. Sarcoplasmic reticulum calcium leak drives ventricular arrhythmias rather than heart failure progression, as rycal S36 treatment markedly reduces arrhythmias and improves survival in mice.
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