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A highly efficient asymmetric conjugate addition of carbonyl donors to α, β-unsaturated aldehydes is realized with 6′-OH cinchona alkaloids as bifunctional organocatalysts. A wide range of α-substituted β-ketoesters and α-substituted α-cyanoacetates can be employed as donors, whereas acrolein and β-substituted α, β-unsaturated aldehydes are suitable acceptors for this enantioselective addition. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2006/z600867ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Wu et al. (Wed,) studied this question.