Key result
Chronic disturbance of the biological rhythm is associated with an increased risk for cardiovascular diseases, while melatonin shows potential as an antihypertensive and cardioprotective agent.
Why the study?
The circadian rhythm regulates essential cardiovascular functions, prompting a review of how interactions between environmental/behavioral stressors and circadian phases modulate individual cardiovascular risk and potential therapeutic targets.
Circadian rhythm disruption significantly impacts cardiovascular risk, highlighting the potential for chronotherapy and melatonin in cardiovascular disease management.
Answers are grounded in this paper and cite their sources.
Circadian assessment may refine CV risk evaluation; leaves open melatonin's therapeutic role pending RCTs.
Circadian rhythm, an internal 24-hour cycle biological clock, regulates important biologic functions such as metabolism, body temperature, heart and respiratory rate, circulating levels of hormones, sleep-wake pattern, behaviour. It is also a very important in regulation of the cardiovascular (CV) system components such as arterial blood pressure, pulse, endothelial function. In this comprehensive review of the literature, we will discuss how interaction between environment/behavior stressors and circadian phases modulate individual cardiovascular risk. Potential therapeutical targets will be also discussed.
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M Radomirovic (2022) conducted a review in Cardiovascular diseases. Circadian rhythm disruption and melatonin was evaluated. Chronic disturbance of the biological rhythm is associated with an increased risk for cardiovascular diseases, while melatonin shows potential as an antihypertensive and cardioprotective agent.
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