What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Healthy aging (n=45). Intervention: Advancing age vs. Younger age (<40 years). Primary outcome: Epicardial adipose tissue (EAT) thickness (p=<0.01).

August 2, 2014BMC Cardiovascular DisordersOpen Access

Increased myocardial dysfunction, dyssynchrony, and epicardial fat across the lifespan in healthy males

Q: What are the key findings of this study?

In healthy males, advancing age was associated with significant increases in epicardial adipose tissue and left ventricular dyssynchrony, which collectively explained 37% of the variance in longitudinal strain.

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Key result

In healthy males, advancing age was associated with significant increases in epicardial adipose tissue and left ventricular dyssynchrony, which collectively explained 37% of the variance in longitudinal strain.

Population

45 healthy males aged 19-94 years, divided into young, middle, and older categories. Exclusion criteria…

Design

Cross-sectional

Authors

ECEdward CrendalUniversity of Newcastle Australia FDFrédéric DutheilCentre National de la Recherche Scientifique GNGéraldine NaughtonMacquarie University

Discussion

Member takes

Implication

Does not support practice change in healthy males; leaves open whether epicardial fat mediates age-related strain decline.

Study Design

Type

Cross-Sectional (n=45)

Multicenter

Structured PICO

Population

45 healthy males aged 19 to 94 years, free of cardiovascular disease, diabetes, and hypertension, evaluated cross-sectionally to assess age-related changes in left ventricular mechanics.

Outcome

Profile of the healthy aging-heart using conventional, tissue-Doppler imaging (TDI) and speckle-tracking echocardiography (STE), and underlying contributions from epicardial adipose tissue (EAT) and LV-dyssynchrony towards LV myocardial mechanicssurrogate

Main Result

Absolute Event Rate: 5.7% vs 2.5%

p-value: p=<0.01

Healthy aging in males is associated with increased epicardial fat and left ventricular dyssynchrony, which independently contribute to age-related declines in myocardial mechanics.

Limitations

Cross-sectional design
Small sample size
Discarding of some poor quality cine-loops due to lack of echogenicity in older participants
Inability to assess STE parameters in the radial axis and apical two-chamber and three-chamber windows
Slightly high intra and inter-observer variability for twisting mechanics and LV-dyssynchrony

Cite This Study

Crendal et al. (2014) conducted a cross-sectional in Healthy aging (n=45). Advancing age vs. Younger age (<40 years) was evaluated on Epicardial adipose tissue (EAT) thickness (p=<0.01). In healthy males, advancing age was associated with significant increases in epicardial adipose tissue and left ventricular dyssynchrony, which collectively explained 37% of the variance in longitudinal strain.

synapsesocial.com/papers/6a21aa38582b7ad9ebabe3df https://doi.org/10.1186/1471-2261-14-95

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Increased myocardial dysfunction, dyssynchrony, and epicardial fat across the lifespan in healthy males

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Increased myocardial dysfunction, dyssynchrony, and epicardial fat across the lifespan in healthy males

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider