Key result
In canine subcutaneous adipose tissue, theophylline, cAMP, ATP, and DBcAMP increased blood flow by approximately 100% and antagonized sympathetic vasoconstriction.
The study supports the view that cAMP mediates the metabolic actions of sympathetic nerve stimulation in canine subcutaneous adipose tissue, though its role in vascular reactions may be more complex.
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These canine findings should not change clinical practice; leaves open cAMP's vascular role in human adipose tissue.
Bertil B. Fredholm (1974) studied this question. Theophylline, DBcAMP, DBcGMP, cAMP, ATP was evaluated on Blood flow and metabolic parameters (glycerol release, FFA release, glucose uptake). In canine subcutaneous adipose tissue, theophylline, cAMP, ATP, and DBcAMP increased blood flow by approximately 100% and antagonized sympathetic vasoconstriction.
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