Key result
Obesity induction in young rats significantly increased the number of foam cells in the thoracic aorta compared to non-obese rats (29.2 vs 1.6, p=0.008), which strongly correlated with plasma ET-1 levels.
Why the study?
This study aimed to evaluate the relationship between serum endothelin-1 levels and the emergence of early atherosclerotic lesions in obesity.
Does a high-carbohydrate and high-fat diet-induced obesity increase plasma endothelin-1 levels and early atherosclerotic lesion formation in young male Wistar rats?
Does a high-carbohydrate and high-fat diet-induced obesity increase plasma endothelin-1 levels and early atherosclerotic lesion formation in young male Wistar rats?
In a young rat model, diet-induced obesity significantly increased early atherosclerotic lesion formation (foam cells), which strongly correlated with plasma endothelin-1 levels.
Associates diet-induced obesity with early aortic lesions via ET-1 in young rats; leaves open translation to human atherosclerosis prevention.
Background: Obesity has a strong relationship with the acceleration of initial atherosclerosis lesion formation that marked by increasing of some biomarkers such as endothelin-1 (ET-1). Obesity also becomes a risk factor for the emergence of various metabolic diseases like hypertension and type 2-diabetes. This study aims to reveal the relation of endothelin-1 serum levels with the early lesion of atherosclerosis. Results: There were an increasing value in serum ET-1 level and aorta foam cells count in obese group compared to normal group. Furthermore, there is a strong positive correlation between serum ET-1 level and the amount of aorta foam cells (r = 0.628) in young obese rats. Conclusions: ET-1 showed an important role to triggering the emergence of early lesions in of atherosclerosis in young age obese rat.
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Sandira et al. (2022) studied Obesity and early atherosclerotic lesions (n=10). High carbohydrates and high fat diet vs. Standard diet was evaluated on Foam cell count in the thoracic aorta (p=0.008). Obesity induction in young rats significantly increased the number of foam cells in the thoracic aorta compared to non-obese rats (29.2 vs 1.6, p=0.008), which strongly correlated with plasma ET-1 levels.
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