Key result
Compared with men, maximum leg blood flow increments to methacholine were higher in lean (347% vs 231%, P<0.05) and obese women (203% vs 111%, P<0.01), but this sex difference was lost in diabetes.
Why the study?
Does type II diabetes abrogate sex differences in endothelial function in premenopausal women compared to men?
Cross-Sectional
Does type II diabetes abrogate sex differences in endothelial function in premenopausal women compared to men?
Type II diabetes eliminates the protective endothelial function advantage typically seen in premenopausal women, leading to endothelial dysfunction similar to that of diabetic men.
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Diabetes may erase premenopausal women's endothelial advantage; hypothesis-generating for sex-specific vascular risk in diabetes.
Steinberg et al. (2000) conducted a cross-sectional in Obesity and Type II Diabetes. Female sex vs. Male sex was evaluated on Maximum leg blood flow increments in response to methacholine chloride. Compared with men, maximum leg blood flow increments to methacholine were higher in lean (347% vs 231%, P<0.05) and obese women (203% vs 111%, P<0.01), but this sex difference was lost in diabetes.
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