What question did this study set out to answer?

To evaluate the prospective relationship between endothelium-dependent vasodilation and the incidence of type 2 diabetes in healthy postmenopausal women.

March 1, 2005Diabetes CareOpen Access

Endothelial-Dependent Vasodilation and Incidence of Type 2 Diabetes in a Population of Healthy Postmenopausal Women

View Full Paper

Ask AI

Bookmark

Why the study?

Does impaired endothelial-dependent vasodilation increase the incidence of type 2 diabetes in healthy postmenopausal women?

Population

840 apparently healthy, nonobese, postmenopausal women, mean age 53 +/- 6 years, initially with normal…

Comparison

Impaired endothelial function, measured as… vs Normal endothelial function, measured as FMD in…

Design

Cohort

Follow-up

mean 3.9 +/- 0.7 years

Authors

RRRosario RossiUniversity of Modena and Reggio Emilia ECElena CioniAzienda Sanitaria Unità Locale di Reggio Emilia ANAnnachiara NuzzoOspedale "Santa Maria delle Croci" di Ravenna

Discussion

Member takes

Implication

May identify high-risk postmenopausal women; extends vascular marker evidence but should not yet alter prevention strategies.

Key Points

To evaluate the prospective relationship between endothelium-dependent vasodilation and the incidence of type 2 diabetes in healthy postmenopausal women.
Prospective cohort study initiated in 1997 following 840 healthy, nonobese postmenopausal women (aged 53 ± 6 years) with normal baseline oral glucose tolerance.
Follow-up duration averaged 3.9 ± 0.7 years (range 0.5–6.9 years).
Endothelial function was measured as flow-mediated dilation (FMD) of the brachial artery using high-resolution ultrasound.
Over the follow-up period, 102 women developed incident type 2 diabetes.
Women in the lowest FMD tertile (≤4.3%) had a significantly elevated risk of developing diabetes compared with the highest tertile reference group (≥5.6%), with an adjusted RR of 5.87 (95% CI 4.34–8.10).
Each 1-unit decrease in FMD was associated with a 32% increase in the multiple-adjusted relative risk of incident diabetes (RR 1.32, 95% CI 1.22–1.48).

Structured PICO

Does impaired endothelial-dependent vasodilation increase the incidence of type 2 diabetes in healthy postmenopausal women?

Population

840 apparently healthy, nonobese, postmenopausal women, mean age 53 +/- 6 years, initially with normal glucose tolerance at the oral glucose tolerance test.

Intervention

Impaired endothelial function, measured as flow-mediated dilation (FMD) of the brachial artery in the lowest tertile (≤4.3).

Comparator

Normal endothelial function, measured as FMD in the highest tertile (≥5.6).

Outcome

Incidence of type 2 diabetes

Impaired endothelial function, as measured by lower flow-mediated dilation, is strongly associated with an increased risk of developing type 2 diabetes in healthy postmenopausal women.

Cite This Study

Rossi et al. (2005) studied this question.

synapsesocial.com/papers/6a766ec87918a3661729522d https://doi.org/10.2337/diacare.28.3.702

View Full Paper

Ask AI

Bookmark

Endothelial-Dependent Vasodilation and Incidence of Type 2 Diabetes in a Population of Healthy Postmenopausal Women

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Endothelial-Dependent Vasodilation and Incidence of Type 2 Diabetes in a Population of Healthy Postmenopausal Women

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider