A history of gestational diabetes mellitus was associated with significantly decreased flow-mediated dilatation compared to healthy controls (1.6% vs 10.3%, P<0.001).
Cross-Sectional (n=52)
Does a history of gestational diabetes mellitus impair endothelium-dependent vasodilatation in otherwise healthy women?
Endothelial dysfunction, an early marker of atherogenesis, is present in women with a history of gestational diabetes even when they have normal glucose tolerance.
Absolute Event Rate: 1.6% vs 10.3%
p-value: p=<0.001
OBJECTIVE: To assess whether otherwise healthy women with a history of gestational diabetes mellitus (GDM) may have abnormalities in endothelial function at a very early stage, before glucose intolerance occurs. RESEARCH DESIGN AND METHODS: A total of 33 women with previous GDM (17 nonobese BMI or = 27) and 19 healthy nonobese women were examined. A 75-g oral glucose tolerance test was performed, and insulin levels and biochemical parameters were also measured. Using high-resolution ultrasound, we measured vasodilatory responses of the brachial artery during reactive hyperemia (endothelium-dependent vasodilatation), and after nitroglycerin administration, an endothelium-independent vasodilator. RESULTS: Flow-mediated dilatation (FMD) was significantly and equally decreased in both groups of women with previous GDM, compared with control subjects (1.6 +/- 3.7% in the nonobese GDM group and 1.6 +/- 2.5% in the obese GDM group vs. 10.3 +/- 4.4% in control subjects, P < 0.001). FMD correlated inversely with serum uric acid levels, BMI, serum total cholesterol, and basal insulin resistance (homeostasis model assessment). Nitrate-induced dilatation was significantly decreased only in the obese GDM group compared with control subjects, (21.4 +/- 5.1 vs. 27.9 +/- 9.5, P < 0.05). CONCLUSIONS: Endothelial dysfunction, which is considered as a very early index of atherogenesis, is already present in both obese and nonobese women with a history of GDM, even when they have normal glucose tolerance.
Anastasiou et al. (Tue,) conducted a cross-sectional in History of gestational diabetes mellitus (n=52). History of gestational diabetes mellitus vs. Healthy nonobese women was evaluated on Flow-mediated dilatation (FMD) during reactive hyperemia (p=<0.001). A history of gestational diabetes mellitus was associated with significantly decreased flow-mediated dilatation compared to healthy controls (1.6% vs 10.3%, P<0.001).