Key result
Gestational diabetes mellitus was associated with lower mean flow-mediated dilation compared to normal pregnancy at 24-28 weeks (11.22% vs 14.49%), although the difference was not statistically significant.
Why the study?
The study was conducted to assess vascular function in normal pregnant women versus those with gestational diabetes and to evaluate its temporal relationship with gestational age and the postpartum period.
Does gestational diabetes mellitus impair endothelial function as assessed by flow-mediated dilation compared to normal pregnancy?
Cohort (n=74)
No
Does gestational diabetes mellitus impair endothelial function as assessed by flow-mediated dilation compared to normal pregnancy?
Absolute Event Rate: 11.22% vs 14.49%
p-value: p=not significant
Endothelial function declines significantly in the third trimester of pregnancy in both GDM and healthy pregnancies, with no significant difference between the two groups, though FMD negatively correlates with BMI and HbA1c.
FMD decline during late pregnancy occurs similarly regardless of GDM status; leaves open endothelial dysfunction's role in GDM-related CVD risk.
Background: The objective of the study was to assess vascular function in normal pregnant women and women with gestational diabetes and to study its temporal relationship with gestational age at 24-28-week POG and at 36-38-week POG and changes in FMD in postpartum period.Methods: Assessment of vascular function was done at 24-28-week POG, 36-38-week POG and at 6-12-week postpartum by flow mediated dilation of brachial artery in 37 healthy pregnant women and 37 pregnant women with GDM.Results: In GDM group mean FMD at 24-28 weeks of POG, at 36-38 weeks POG was lower as compared to the control group (11.225±6.20,8.464±6.09 versus 14.49±5.21, 10.898±4.12) although the difference in mean FMD in two groups was not statistically significant. It was found that the decrease in FMD at 36-38-week POG as compared to 24-28 weeks POG was statistically significant in both the groups (p<0.001).Conclusions: This study revealed that when endothelial function as assessed by FMD was compared at different period of gestation, the mean decrease in FMD at 36-38-week POG as compared to 24-28-week POG and 6-week post-partum was statistically significant in patients with GDM and as well as the control group, however this trend of change was same in both the groups and was not statistically significant when compared between the two group (GDM versus control). A negative correlation of FMD was found with BMI, and HBA1c, that was stronger in GDM group.
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Pandey et al. (2020) conducted a cohort in Gestational diabetes mellitus (n=74). Gestational diabetes mellitus vs. Normal pregnancy was evaluated on Mean flow-mediated dilation (FMD) at 24-28 weeks of gestation (p=not significant). Gestational diabetes mellitus was associated with lower mean flow-mediated dilation compared to normal pregnancy at 24-28 weeks (11.22% vs 14.49%), although the difference was not statistically significant.
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