Key result
The KV7 channel openers flupirtine and retigabine cause intolerable side effects such as drug-induced liver injury and blue tissue discoloration, necessitating the development of safer substitutes.
Why the study?
Flupirtine and retigabine showed intolerable adverse effects unrelated to their shared mechanism of action, prompting the need to clarify their toxicity and explore safer KV7 channel opener substitutes.
The review highlights the severe adverse effects of flupirtine and retigabine and discusses strategies for developing safer KV7 channel openers.
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Clinicians should avoid flupirtine and retigabine; leaves open safer KV7 openers for future trials.
Bock et al. (2019) reported a review. Flupirtine and retigabine was evaluated. The KV7 channel openers flupirtine and retigabine cause intolerable side effects such as drug-induced liver injury and blue tissue discoloration, necessitating the development of safer substitutes.
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