Key result
Higher 24-hour systolic BP and untreated hypertension are linked to increased arterial stiffness in young stroke survivors.
Why the study?
Information about factors associated with progressive arterial stiffening during the follow-up of young patients with ischemic stroke is lacking.
What factors are associated with the progression of arterial stiffness in young ischemic stroke survivors?
Cohort (n=271)
What factors are associated with the progression of arterial stiffness in young ischemic stroke survivors?
In young ischemic stroke survivors, progression of arterial stiffness over 5.5 years is associated with higher systolic blood pressure and lack of antihypertensive treatment, highlighting the importance of blood pressure control.
Answers are grounded in this paper and cite their sources.
May inform BP management in young ischemic stroke survivors; leaves open whether stiffness progression influences outcomes.
BACKGROUND: Progressive arterial stiffening may increase the risk of recurrent cardiovascular events in ischemic stroke survivors. Information about factors associated with progressive arterial stiffening during the follow-up of young patients with ischemic stroke is lacking. METHODS: Arterial stiffness by carotid-femoral pulse wave velocity (cf-PWV) and ambulatory 24-hour blood pressure (24hBP) were assessed in 81 women and 190 men ≤60 years of age included in the Norwegian Stroke in the Young (NOR-SYS) study 3 months and 5.5 years after the incident ischemic stroke, representing baseline and follow-up. Covariables of change in cf-PWV were identified using linear regression analysis. RESULTS: At baseline, women had less prevalent hypertension (53% vs. 69%, p < 0.05), and lower clinic and 24hBP than men, whereas age, obesity, and prevalence of smoking and antihypertensive drug treatment did not differ. During follow-up, systolic 24hBP remained unchanged, while diastolic 24hBP fell significantly (p < 0.01). Cf-PWV was lower in women both at baseline (7.3 m/s vs. 8.1 m/s) and at follow-up (7.3 m/s vs. 8.0 m/s, both p < 0.001), but the average change during follow-up did not differ between genders. In linear regression analysis, an increase in cf-PWV at the 5-year follow-up was associated with the presence of hypertension and lower cf-PWV at baseline, and higher systolic 24hBP and lack of use of antihypertensive treatment at follow-up (all p < 0.05). CONCLUSION: In ischemic stroke survivors participating in the NOR-SYS study, the 5-year increase in cf-PWV did not differ between genders and was associated with higher systolic 24hBP and lack of antihypertensive treatment.
No takes yet. Share an insight, caveat, or question.
Eilertsen et al. (2024) conducted a cohort in Ischemic stroke (n=271). Higher systolic 24-hour blood pressure and lack of antihypertensive treatment vs. Lower systolic 24-hour blood pressure and use of antihypertensive treatment was evaluated on Increase in carotid-femoral pulse wave velocity (cf-PWV) at 5-year follow-up (p=<0.05). In young ischemic stroke survivors, a 5-year increase in arterial stiffness was associated with higher systolic 24-hour blood pressure and lack of antihypertensive treatment (all p<0.05).
Synapse has enriched 10 related papers. Consider them for comparative context: