Key result
The GT repeat in the human cardiac Na+/Ca2+ exchanger intron 2 acts as a strong intronic splicing enhancer required for splicing activation.
A polymorphic GT repeat in intron 2 of the human cardiac NCX1 gene acts as a strong intronic splicing enhancer, potentially regulating NCX1 expression.
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Hypothesis-generating for NCX1 splicing variants in heart disease; leaves open human clinical relevance.
Nadia Gabellini (2001) studied this question. GT repeat in NCX1 intron 2 was evaluated on Splicing activation. The GT repeat in the human cardiac Na+/Ca2+ exchanger intron 2 acts as a strong intronic splicing enhancer required for splicing activation.
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