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Twenty one patients with Hodgkin's disease who were in relapse following extensive radiation therapy were treated with a combination chemotherapy program (MOPP), which included nitrogen mustard, vincristine, prednisone, and procarbazine for 6 monthly cycles. Sixteen patients (76 per cent) achieved complete remission. In a comparable group of patients with extensive disease but no previous radiotherapy the over‐all remission rate and the degree of myelosuppression were similar. The interval between the end of radiotherapy and the onset of chemotherapy did not correlate with the extent of subsequent drug tOXicity. Relapse of Hodgkin's disease in the patients following intensive radiotherapy with curative intent does not preclude a subsequent excellent response to combination chemotherapy and a prolonged disease‐free interval.
Canellos et al. (Fri,) studied this question.