Key result
Dysregulation of the adenosine receptor system with aging contributes to the decline in intrinsic cardioprotective responses and increased ischemic intolerance in the aged myocardium.
Population
aging myocardium / aged hearts
Design
Review
Authors
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May support adenosine receptor modulation in elderly ischemia; leaves open clinical efficacy pending prospective trials.
Dysregulation of the adenosine receptor system contributes to ischemic intolerance in the aging myocardium, and its manipulation may restore cardioprotective responses.
Willems et al. (2004) conducted a review in Ischemic disorders in the aging myocardium. Adenosine receptor system was evaluated. Dysregulation of the adenosine receptor system with aging contributes to the decline in intrinsic cardioprotective responses and increased ischemic intolerance in the aged myocardium.
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