Key result
Lower peak flow rate (<430 L/min) was associated with increased CHD mortality compared to ≥550 L/min (HR 1.53; 95% CI 1.04-2.25), but evidence was limited after adjusting for other risk factors.
Why the study?
Is peak flow rate an independent risk factor for coronary heart disease mortality in men?
Cohort (n=2,167)
Is peak flow rate an independent risk factor for coronary heart disease mortality in men?
Hazard Ratio: 1.53 (95% CI 1.04–2.25)
p-value: p=0.025
After adjusting for other cardiovascular risk factors, there is only limited evidence of an independent association between peak flow rate and long-term CHD mortality.
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Peak flow rate should not yet inform CHD risk assessment in men; leaves open whether it adds independent prognostic value after full adjustment.
Clayton et al. (2014) conducted a cohort in Coronary heart disease (n=2,167). Peak flow rate vs. Peak flow rate ≥550 L/min was evaluated on CHD mortality (HR 1.53, 95% CI 1.04 to 2.25, p=0.025). Lower peak flow rate (<430 L/min) was associated with increased CHD mortality compared to ≥550 L/min (HR 1.53; 95% CI 1.04-2.25), but evidence was limited after adjusting for other risk factors.
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