Key result
Pulmonary function (%PFEV1) was significantly inversely related to coronary heart disease incidence (p=0.0004), but this association was explained by cigarette smoking.
Why the study?
Does pulmonary function predict the development of coronary heart disease in men free of coronary heart disease at baseline?
Cohort (n=5,924)
Does pulmonary function predict the development of coronary heart disease in men free of coronary heart disease at baseline?
p-value: p=0.0004
The association between reduced pulmonary function and incident coronary heart disease appears to be confounded by cigarette smoking rather than being an independent risk factor.
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Reduced pulmonary function should not inform CHD risk assessment beyond smoking status; confirms confounding by smoking in this cohort.
Marcus et al. (1989) conducted a cohort in Coronary heart disease (n=5,924). Pulmonary function (%PFEV1) was evaluated on development of nonfatal myocardial infarction and fatal coronary heart disease (p=0.0004). Pulmonary function (%PFEV1) was significantly inversely related to coronary heart disease incidence (p=0.0004), but this association was explained by cigarette smoking.
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