Key result
Among hypertensive men, reduced lung function was associated with significantly higher rates of cardiac events (27.1 vs 12.8/1,000 person-years) and mortality compared to high lung function.
Why the study?
Does reduced lung function increase the risk of mortality, stroke, and cardiac events in hypertensive men?
Cohort (n=639)
No
Does reduced lung function increase the risk of mortality, stroke, and cardiac events in hypertensive men?
Absolute Event Rate: 27.1% vs 12.8%
Reduced lung function is an independent risk factor for cardiovascular events and mortality in hypertensive men, suggesting a synergistic interaction between hypertension and lung function.
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May refine CV risk stratification in hypertensive men; extends observational data but leaves causal effects and interventions open.
Engström et al. (2001) conducted a cohort in Hypertension (n=639). Reduced lung function (FEV1.0 below median) vs. High lung function (FEV1.0 above median) was evaluated on Cardiac events (fatal or non-fatal myocardial infarction). Among hypertensive men, reduced lung function was associated with significantly higher rates of cardiac events (27.1 vs 12.8/1,000 person-years) and mortality compared to high lung function.
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