Key result
Elderly patients with idiopathic orthostatic hypotension had a significantly smaller and slower rise in heart rate within 40 seconds of standing compared to controls (P<0.05).
Why the study?
Does standing elicit different heart-rate changes in elderly patients with orthostatic hypotension compared to controls?
Case-Control (n=36)
Does standing elicit different heart-rate changes in elderly patients with orthostatic hypotension compared to controls?
p-value: p=<0.05
Elderly patients with orthostatic hypotension exhibit a blunted heart rate response to standing, indicating a failure of the autonomic reflex.
Blunted early heart-rate rise may aid evaluation of elderly orthostatic hypotension; leaves open prognostic value and therapeutic implications.
The heart-rate changes on standing were studied in 16 elderly patients with idiopathic orthostatic hypotension and compared with those of 20 controls. The mean age of both groups was 78 years, and all were in sinus rhythm. 2. The patients with orthostatic hypotension differed from the control patients in having no early peak in heart rate, and a significantly smaller and slower rise in heart rate within the first 40 s after standing (P less than 0.05). 3. It is concluded that there is a failure of the autonomic reflex in elderly patients with orthostatic hypotension, which may contribute towards their symptoms.
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Nicholas J. White (1980) conducted a case-control in Idiopathic orthostatic hypotension (n=36). Idiopathic orthostatic hypotension vs. Controls was evaluated on Heart-rate changes on standing within the first 40 seconds (p=<0.05). Elderly patients with idiopathic orthostatic hypotension had a significantly smaller and slower rise in heart rate within 40 seconds of standing compared to controls (P<0.05).
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