What question did this study set out to answer?

This research aims to explore the role of autonomic failure in elderly patients with orthostatic hypotension.

June 1, 1983Clinical Science

Do Elderly Patients with An Excessive Fall in Blood Pressure on Standing Have Evidence of Autonomic Failure?

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Orthostatic hypotension. Intervention: Orthostatic hypotension vs. Control group (systolic blood pressure fall <15 mmHg on standing). Primary outcome: Plasma noradrenaline concentrations and heart rate response on standing (p=<0.05).

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Key result

Elderly patients with orthostatic hypotension had lower supine plasma noradrenaline (P<0.01) but a greater percentage increase during standing (P<0.05) compared to controls.

Population

Elderly subjects, divided into a control group and an orthostatic hypotension group.

Design

Cross-sectional

Authors

BRBrian RobinsonCornell University RJRalph H. JohnsonMedical University of South Carolina DLD. G. LambieWellington Hospital

Discussion

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Implication

May suggest mechanical or adrenoreceptor causes over autonomic failure; hypothesis-generating pending prospective studies.

Key Points

This research aims to explore the role of autonomic failure in elderly patients with orthostatic hypotension.
Two groups of elderly subjects were examined based on blood pressure responses to standing: control (less than 15 mmHg fall) and orthostatic hypotension (more than 20 mmHg fall).
Measurements included blood pressure, heart rate, and plasma catecholamine levels during supine and standing positions.
Statistical analysis was performed to compare noradrenaline concentrations and blood pressure differences between the two groups.
The orthostatic hypotension group exhibited lower plasma noradrenaline levels in supine position compared to controls (P < 0.01).
During standing, the percentage increase of noradrenaline levels was greater in orthostatic hypotension patients (P < 0.05).
Diastolic blood pressure was significantly higher in the orthostatic hypotension group in the supine position (P < 0.05).

Study Design

Type

Observational

Structured PICO

Population

Elderly subjects with and without orthostatic hypotension evaluated for blood pressure, heart rate, and plasma catecholamine responses to standing.

Outcome

Blood pressure, heart rate and plasma catecholamine (noradrenaline) responses to standingsurrogate

Main Result

p-value: p=<0.05

Orthostatic hypotension in the elderly does not appear to be driven by impaired baroreceptor function or reduced sympathetic nervous activity, suggesting mechanical or adrenoreceptor dysfunction as more likely causes.

Cite This Study

Robinson et al. (1983) conducted an observational in Orthostatic hypotension. Orthostatic hypotension vs. Control group (systolic blood pressure fall <15 mmHg on standing) was evaluated on Plasma noradrenaline concentrations and heart rate response on standing (p=<0.05). Elderly patients with orthostatic hypotension had lower supine plasma noradrenaline (P<0.01) but a greater percentage increase during standing (P<0.05) compared to controls.

synapsesocial.com/papers/6a230d293bf314e836cb2c3b https://doi.org/10.1042/cs0640587

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Do Elderly Patients with An Excessive Fall in Blood Pressure on Standing Have Evidence of Autonomic Failure?

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Do Elderly Patients with An Excessive Fall in Blood Pressure on Standing Have Evidence of Autonomic Failure?

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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