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February 24, 2003CirculationOpen Access

His Electrogram Alternans Reveal Dual Atrioventricular Nodal Pathway Conduction During Atrial Fibrillation

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Why the study?

Does slow-pathway modification guided by His electrogram alternans increase the His-His interval during atrial fibrillation in rabbit AVN preparations?

Population

12 rabbit atrioventricular nodal (AVN) preparations

Comparison

Slow-pathway modification guided by His… vs Baseline (before SP modification)

Design

Preclinical

Authors

YZYouhua ZhangSBSaroja BharatiKMKent A. Mowrey

Discussion

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Overview

Hypothesis-generating for rate control via targeted SP ablation in AF; leaves open translation to human therapy.

Structured PICO

Does slow-pathway modification guided by His electrogram alternans increase the His-His interval during atrial fibrillation in rabbit AVN preparations?

P
Population
12 rabbit atrioventricular nodal (AVN) preparations
I
Intervention
Slow-pathway (SP) modification guided by His electrogram (HE) alternans during atrial fibrillation
C
Comparator
Baseline (before SP modification)
O
Outcome
Change in average His-His interval and presence of dual pathways indicated by HE alternanssurrogate

His electrogram alternans can identify dual-pathway AV nodal conduction during AF and guide selective slow-pathway ablation to slow the ventricular rate in a rabbit model.

Cite This Study

Zhang et al. (2003) studied this question.

synapsesocial.com/papers/6a21c3f03f99faaa70eca971https://doi.org/10.1161/01.cir.0000051464.52601.f4
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