Key result
Cilostazol significantly increased minimal heart rate by an average of 14 bpm and mean heart rate by 18 bpm in patients with chronic atrial fibrillation and bradycardia.
Why the study?
Does cilostazol improve heart rate and its variation in patients with chronic atrial fibrillation associated with bradycardia episodes?
Population
13 patients with chronic atrial fibrillation associated with bradycardia episodes
Comparison
Cilostazol 100 or 200 mg/day orally for at least… vs Baseline (pre-treatment)
Design
Case_series
Follow-up
at least 2 months
Authors
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May support rate augmentation in select AF-bradycardia cases; leaves open randomized confirmation before practice change.
Does cilostazol improve heart rate and its variation in patients with chronic atrial fibrillation associated with bradycardia episodes?
Mean Difference: 14
Cilostazol effectively increases heart rate and reduces pauses in patients with chronic atrial fibrillation and bradycardia without altering heart rate variability.
Toyonaga et al. (2000) studied Chronic atrial fibrillation associated with bradycardia episodes (n=13). Cilostazol vs. Baseline (pre-treatment) was evaluated on Minimal heart rate (MD 14 bpm). Cilostazol significantly increased minimal heart rate by an average of 14 bpm and mean heart rate by 18 bpm in patients with chronic atrial fibrillation and bradycardia.
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