August 1, 1994Journal of Cardiovascular Pharmacology
Rapid Development of Nitrate Tolerance in Healthy Volunteers
Why the study?
Does continuous nitroglycerin patch therapy reduce the hypotensive and sympathetic activation effects of rapid i.v. nitroglycerin in healthy male volunteers?
Population
11 healthy male volunteers
Comparison
Continuous nitroglycerin patch therapy for 22.5… vs Before NTG patch and 22.5 hours after patch…
Design
Other
Follow-up
3 consecutive days
Authors
Discussion
Loading...
Member takes
Implication
Volunteer data on rapid tolerance should not change nitrate use; leaves open relevance to patient dosing strategies.
Structured PICO
Does continuous nitroglycerin patch therapy reduce the hypotensive and sympathetic activation effects of rapid i.v. nitroglycerin in healthy male volunteers?
P
Population
11 healthy male volunteers
I
Intervention
Continuous nitroglycerin (NTG) patch therapy for 22.5 hours
C
Comparator
Before NTG patch and 22.5 hours after patch removal (intra-subject comparison)
O
Outcome
Maximum decrease in systolic blood pressure (SBP), maximum reflex tachycardia, and sympathetic activation (low-frequency oscillations in SBP) produced by rapid i.v. infusion of 0.45 mg NTGsurrogate
Continuous transdermal nitroglycerin therapy for 22.5 hours induces rapid nitrate tolerance, significantly blunting the hypotensive and sympathetic activation effects of intravenous nitroglycerin.
Cite This Study
Cloarec-Blanchard et al. (1994) studied this question.