May 1, 1996British Journal of PharmacologyOpen Access

Baroreflex resetting but no vascular tolerance in response to transdermal glyceryl trinitrate in conscious rabbits

View Full Paper

Ask AI

Bookmark

Why the study?

Does transdermal glyceryl trinitrate cause haemodynamic and vascular tolerance in conscious rabbits?

Population

Conscious rabbits with an implanted inflatable cuff, pulsed Doppler flow probe, and indwelling intra-aortic…

Comparison

Transdermal glyceryl trinitrate patches… vs Sham patch for acute experiments; baseline…

Design

Preclinical

Follow-up

Up to 8 days

Authors

ASAdrian SeroneGilead Sciences (United States)JAJames A. AngusVascular / Pulmonary Vascular CWChristine E. WrightThe University of Melbourne

Discussion

Member takes

Implication

Suggests baroreflex resetting over vascular tolerance with chronic GTN in rabbits; leaves open optimal dosing for clinical translation.

Structured PICO

Does transdermal glyceryl trinitrate cause haemodynamic and vascular tolerance in conscious rabbits?

Population

Conscious rabbits with an implanted inflatable cuff, pulsed Doppler flow probe, and indwelling intra-aortic catheter (n=28; 12 in acute experiments, 16 in chronic experiments).

Intervention

Transdermal glyceryl trinitrate (GTN) patches, administered acutely (10 or 20 mg/24 h for 5 hours) or chronically (10 or 20 mg/24 h for 4 days, renewed every 24 hours).

Comparator

Sham patch (0 mg GTN) for acute experiments; baseline (day 0) measurements for chronic experiments.

Outcome

Haemodynamic tolerance (arterial pressure, heart rate, and baroreflex control of heart rate) and vascular tolerance (hindquarter vascular reactivity in response to dilator and constrictor drugs and reactive hyperaemia).surrogate

In a rabbit model, chronic transdermal nitrate therapy leads to haemodynamic compensation and baroreflex resetting rather than vascular tolerance, suggesting that intermittent dosing may prevent haemodynamic resetting.

Cite This Study

Serone et al. (1996) studied this question.

synapsesocial.com/papers/6a848cf62327ba91ab8d9858 https://doi.org/10.1111/j.1476-5381.1996.tb15371.x

View Full Paper

Ask AI

Bookmark

Baroreflex resetting but no vascular tolerance in response to transdermal glyceryl trinitrate in conscious rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Baroreflex resetting but no vascular tolerance in response to transdermal glyceryl trinitrate in conscious rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider