August 1, 1994Journal of Cardiovascular Pharmacology
Rapid Development of Nitrate Tolerance in Healthy Volunteers
Why the study?
Does continuous transdermal nitroglycerin therapy induce rapid nitrate tolerance in healthy volunteers?
Population
11 healthy male volunteers
Comparison
Continuous transdermal nitroglycerin patch… vs Baseline and 22.5 hours after patch removal
Design
Other
Follow-up
3 consecutive days
Authors
Discussion
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Member takes
Implication
May prompt intermittent transdermal NTG dosing; leaves open clinical impact in patients with cardiovascular disease.
Structured PICO
Does continuous transdermal nitroglycerin therapy induce rapid nitrate tolerance in healthy volunteers?
P
Population
11 healthy male volunteers
I
Intervention
Continuous transdermal nitroglycerin (NTG) patch therapy for 22.5 hours, tested with rapid intravenous infusion of 0.45 mg NTG in 1 min
C
Comparator
Baseline (before NTG patch) and 22.5 hours after patch removal
O
Outcome
Maximum decrease in systolic blood pressure (SBP), maximum reflex tachycardia, and sympathetic activation (low-frequency oscillations in BP and HR) produced by i.v. NTGsurrogate
Continuous transdermal nitroglycerin therapy induces rapid nitrate tolerance within 22.5 hours, which can be detected by attenuated blood pressure and sympathetic responses to intravenous nitroglycerin.
Cite This Study
Cloarec-Blanchard et al. (1994) studied this question.