Glycemic Control, Atherosclerosis, and Risk Factors for Cardiovascular Disease in Individuals With Diabetes
Key result
Being in the highest quartile of HbA1c was associated with increased odds of being in the highest quartile of carotid IMT in diagnosed (OR 2.62; 95% CI 1.36-5.06) and undiagnosed diabetes.
Why the study?
Is glycemic control (HbA1c) associated with carotid intima-media thickness and cardiovascular risk factors in individuals with diabetes?
Population
2,060 individuals with diagnosed and undiagnosed diabetes from the Atherosclerosis Risk in Communities study
Comparison
Higher HbA1c levels (highest quartile) vs Lower HbA1c levels (lowest quartile)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May aid CV risk stratification in diabetes; leaves open whether glycemic control modifies carotid IMT progression.
Study Design
Type
Cross-Sectional (n=2,060)
Structured PICO
Is glycemic control (HbA1c) associated with carotid intima-media thickness and cardiovascular risk factors in individuals with diabetes?
P
Population
2,060 individuals with diagnosed and undiagnosed diabetes from the Atherosclerosis Risk in Communities study.
E
Exposure
Higher HbA1c levels (highest quartile)
C
Comparator
Lower HbA1c levels (lowest quartile)
O
Outcome
Carotid intima-media thickness (IMT)surrogate
Main Result
Odds Ratio: 2.62 (95% CI 1.36–5.06)
Chronically elevated glucose levels (HbA1c) are independently associated with increased carotid intima-media thickness, suggesting a role in atherosclerosis development independent of other risk factors.
Cite This Study
Selvin et al. (2005) conducted a cross-sectional in Diagnosed and undiagnosed diabetes (n=2,060). Highest quartile of HbA1c vs. Lowest quartile of HbA1c was evaluated on Highest quartile of carotid intima-media thickness (IMT) versus the lowest (OR 2.62, 95% CI 1.36-5.06). Being in the highest quartile of HbA1c was associated with increased odds of being in the highest quartile of carotid IMT in diagnosed (OR 2.62; 95% CI 1.36-5.06) and undiagnosed diabetes.