Key result
Intracellular dialysis demonstrated that intracellular calcium regulates restitution of L-type calcium channels in mammalian ventricular myocytes (ICa amplitude 2.2 nA in guinea pig vs 0.9 nA in dog).
Population
Dog or guinea pig ventricular myocytes (n=8 for both)
Comparison
Intracellular dialysis to vary the intracellular… vs Control level (normal intracellular environment)
Design
Preclinical
Authors
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May inform calcium handling studies in animal models; leaves open relevance to human ventricular arrhythmias.
Intracellular calcium regulates the restitution of L-type calcium channels in mammalian ventricular myocytes, a process involving the sarcoplasmic reticulum.
Gea‐Ny Tseng (1988) studied this question. Intracellular dialysis (varying intracellular calcium) vs. Control level was evaluated on L-type calcium current (ICa) restitution and overshoot. Intracellular dialysis demonstrated that intracellular calcium regulates restitution of L-type calcium channels in mammalian ventricular myocytes (ICa amplitude 2.2 nA in guinea pig vs 0.9 nA in dog).
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