Key result
PAKa is required for completing cytokinesis, maintaining the direction of cell movement, and regulating myosin II assembly in Dictyostelium discoideum cells.
Population
Dictyostelium discoideum cells (paka null cells)
Comparison
Deletion of paka gene or constitutively active… vs Wild-type cells
Design
Preclinical
Authors
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PAKa's role in Dictyostelium extends cytoskeletal models; hypothesis-generating for conserved pathways in mammalian cells.
PAKa is identified as a major regulator of myosin II assembly and is required for cytokinesis and cytoskeleton regulation during chemotaxis in Dictyostelium discoideum.
Chung et al. (1999) studied Dictyostelium discoideum cells. PAKa gene/protein was evaluated on Cytokinesis and cytoskeleton regulation. PAKa is required for completing cytokinesis, maintaining the direction of cell movement, and regulating myosin II assembly in Dictyostelium discoideum cells.
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