Population
Microvascular endothelial cells
Design
Preclinical
Authors
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PAK activity must be balanced for endothelial migration; extends cytoskeletal models but leaves open therapeutic targeting in vascular disease.
PAK plays a crucial role in coordinating the formation of new adhesions at the leading edge with contraction and detachment at the trailing edge during endothelial cell migration.
Kiosses et al. (1999) studied this question.
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