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October 1, 1991Circulation

The Sicilian gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology.

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Design

Guideline

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Implication

Encourages mechanism-based antiarrhythmic selection in practice; extends traditional classifications for precision therapy.

PICO

P
Population
Arrhythmias
I
Intervention / Comparator
Antiarrhythmic drugs classification

Introduces the 'Sicilian Gambit', a novel, multifaceted framework for classifying antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms and molecular targets.

Limitations

  • Referencing is selective and incomplete.

Cite This Study

A 1991 study conducted a review in Arrhythmias. Antiarrhythmic drugs classification was evaluated. The 'Sicilian Gambit' proposes a new operational framework for classifying antiarrhythmic drugs based on molecular targets, arrhythmogenic mechanisms, and clinical considerations.

synapsesocial.com/papers/6a21ce0624cfbbc699159498https://doi.org/10.1161/01.cir.84.4.1831
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The ‘Sicilian Gambit’1991 · 54 citations
  2. 2Antiarrhythmic drug classifications and the clinician: A gambit in the land of chaos1994 · 11 citations
  3. 3Profiles of Aprindine, Cibenzoline, Pilsicainide and Pirmenol in the Framework of the Sicilian Gambit1999 · 56 citations
  4. 4Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008)2010 · 137 citations
  5. 5Classifying Antiarrhythmic Actions: By Facts or Speculation1992 · 92 citations