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January 1, 1999Japanese Circulation Journal-english EditionOpen Access

Profiles of Aprindine, Cibenzoline, Pilsicainide and Pirmenol in the Framework of the Sicilian Gambit

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Authors

IKItsuo KodamaTokyo Institute of TechnologySOSatoshi OgawaNational Institute of Technology, Niihama CollegeHIHiroshi InoueKanazawa University

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Implication

May inform antiarrhythmic selection in Japan; extends Sicilian Gambit framework while leaving comparative outcomes open.

Structured PICO

I
Intervention
Aprindine, cibenzoline, pilsicainide, and pirmenol

This review integrates the pharmacologic profiles of four antiarrhythmic drugs widely used in Japan into the Sicilian Gambit classification system.

Cite This Study

Kodama et al. (1999) studied this question.

synapsesocial.com/papers/6a7993ee162060f9da88fbe6https://doi.org/10.1253/jcj.63.1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Classification of Antiarrhythmic Actions Reassessed After a Decade of New Drugs1984 · 819 citations
  2. 2The Sicilian gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology.1991 · 548 citations
  3. 3Intracellular electrophysiological alterations in canine cardiac conducting tissue induced by aprindine and lignocaine1976 · 43 citations
  4. 4Effects on rabbit cardiac potentials of aprindine and indecainide, a new antiarrhythmic agent, in normoxia and hypoxia1985 · 16 citations
  5. 5Frequency- and Voltage-Dependent Effects of Aprindine on the Upstroke Velocity of Action Potential in Guinea Pig Ventricular Muscles1987 · 18 citations