Key result
Batrachotoxin modifies sodium channels by shifting the peak conductance-voltage and activation-versus-voltage curves about 50 mV in the hyperpolarizing direction and eliminating inactivation.
Population
Hybrid mouse neuroblastoma cells NG108-15
Comparison
Batrachotoxin (BTX) vs Normal sodium channels (untreated cells)
Design
Preclinical
Authors
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Animal Na channel data on batrachotoxin leave open human translation; hypothesis-generating for gating mechanism studies.
Batrachotoxin modifies sodium channel gating by slowing activation steps and eliminating inactivation, shifting activation to more hyperpolarized potentials.
Huang et al. (1982) studied In vitro neuroblastoma cells. Batrachotoxin (BTX) vs. Normal sodium channels was evaluated on Gating kinetics of sodium channels. Batrachotoxin modifies sodium channels by shifting the peak conductance-voltage and activation-versus-voltage curves about 50 mV in the hyperpolarizing direction and eliminating inactivation.
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