Population
Excised membranes of N1E-115 neuroblastoma cells
Comparison
Batrachotoxin exposure vs Normal (unexposed) Na+ channels
Design
Preclinical
Authors
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Batrachotoxin effects on Na+ channels remain preclinical; hypothesis-generating for arrhythmia research without altering current practice.
Batrachotoxin alters voltage-gated Na+ channel kinetics by prolonging the open state and inducing spontaneous openings, which explains the toxin-induced increase in Na+ permeability and subsequent membrane depolarization.
Quandt et al. (1982) studied this question.
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