Key result
Mean plasma renin activity measured by the Schwarz-Mann procedure was 0.62 ng/ml per hour in normotensive volunteers, which was 35% lower when measured by the Squibb procedure.
Why the study?
How do the Schwarz-Mann and Squibb radioimmunoassay kits compare for measuring plasma renin activity, and does PRA correlate with urinary Na/creatin ratio in casual urine specimens?
Cross-Sectional (n=59)
How do the Schwarz-Mann and Squibb radioimmunoassay kits compare for measuring plasma renin activity, and does PRA correlate with urinary Na/creatin ratio in casual urine specimens?
Twenty to thirty percent of patients with essential hypertension have subnormal plasma renin activity (PRA) and lower incidences of stroke and myocardial infarction. NaCl intake influences PRA, which should thus be compared with 24-h urinary sodium excretion. Because such specimens are difficult to collect accurately, we investigated the relation between PRA and sodium in casual (i.e., untimed) urine specimens and found none. However, PRA and urinary Na/creatinine ratio are inversely correlated for casual specimens. This method is useful for screening individuals whose salt intake is low. Mean PRA, measured by the Schwarz-Mann procedure, was 0.62 ± 0.12 (SD) ng/ml per hour for 59 normotensive volunteers, 35% lower by the Squibb procedure.
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Goldberg et al. (1973) conducted a cross-sectional in Normotension (n=59). Schwarz-Mann procedure vs. Squibb procedure was evaluated on Mean plasma renin activity (PRA). Mean plasma renin activity measured by the Schwarz-Mann procedure was 0.62 ng/ml per hour in normotensive volunteers, which was 35% lower when measured by the Squibb procedure.
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