Key result
Orthostatic hypotension was significantly associated with an increased risk of atrial fibrillation (pooled HR 1.51; 95% CI 1.28-1.79; P<0.001) and heart failure.
Why the study?
The relationships between orthostatic hypotension and certain cardiovascular diseases have been inconsistent across studies.
Does orthostatic hypotension increase the risk of atrial fibrillation, heart failure, and other cardiovascular diseases?
Meta-Analysis
Does orthostatic hypotension increase the risk of atrial fibrillation, heart failure, and other cardiovascular diseases?
Hazard Ratio: 1.51 (95% CI 1.28–1.79)
p-value: p=< 0.001
Orthostatic hypotension is significantly associated with an increased risk of developing heart failure, atrial fibrillation, coronary heart disease, and myocardial infarction.
May warrant AF/HF monitoring in patients with orthostatic hypotension; extends observational evidence but leaves causality and intervention effects open.
The relationships between orthostatic hypotension (OH) and some kinds of cardiovascular disease are inconsistent among studies. This updated meta‐analysis was conducted in hopes of producing progress on this topic. A systematic database search was performed in electronic databases, including the Chinese Biomedical Database (CBM), PubMed, Web of Science, and the Cochrane Library. Summary hazard ratio (HR) estimates with 95% confidence intervals (CIs) were calculated by a random‐effects model. Statistical heterogeneity was assessed with Cochran's Q test and the I 2 statistic. From 1462 potentially eligible records, 15 studies met the inclusion criteria. Subjects with OH had a high risk of heart failure (HF) and atrial fibrillation (AF) (pooled HR 1.34, 95% CI 1.17‐1.52, P < 0.001 and pooled HR 1.51, 95% CI 1.28‐1.79, P < 0.001, respectively). This meta‐analysis also showed significant associations between OH and the risks of developing coronary heart disease (CHD) (pooled HR 1.44, 95% CI 1.18‐1.75, P < 0.001) and myocardial infarction (MI) (pooled HR 1.52, 95% CI 1.12‐2.06, P = 0.008). Our study suggests that OH is positively associated with high risks of HF and AF. Moreover, it may be related to high risks of CHD and MI.
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Min et al. (2019) conducted a meta-analysis in Orthostatic hypotension. Orthostatic hypotension vs. Without orthostatic hypotension was evaluated on Atrial fibrillation (HR 1.51, 95% CI 1.28-1.79, p=< 0.001). Orthostatic hypotension was significantly associated with an increased risk of atrial fibrillation (pooled HR 1.51; 95% CI 1.28-1.79; P<0.001) and heart failure.
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